What question did this study set out to answer?

This research examines the impact of gastrointestinal tract involvement on mortality risks in patients with post transplant lymphoproliferative disorder (PTLD).

December 8, 2025BloodOpen Access

Extranodal involvement of the gastrointestinal tract in post transplant lymphoproliferative disorders: Stomach or small bowel involvement increases mortality risk

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Authors

VDVictoria DeVito APAnthea PetersAlberta Health Services

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Implication

Registry analysis found GI tract involvement increases mortality risk in post transplant lymphoproliferative disorder patients, suggesting need for careful monitoring.

Key Points

This research examines the impact of gastrointestinal tract involvement on mortality risks in patients with post transplant lymphoproliferative disorder (PTLD).
Registry analysis of PTLD patients from Edmonton, Alberta, Canada.
Assessment of GI related events such as obstruction, bleeding, and surgery.
Use of Kaplan Meier method for overall survival analysis and Cox regression for predictors of mortality.
55% of patients had GI tract involvement by FDG-PET or biopsy.
53% of patients had died by July 2025, with GI events attributing to some mortalities.
Involvement of stomach or esophagus significantly increased mortality risk (HR 2.75), while small bowel involvement also showed increased risk (HR 1.86).

Cite This Study

DeVito et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d1cd https://doi.org/10.1182/blood-2025-8036

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Implication

Registry analysis found GI tract involvement increases mortality risk in post transplant lymphoproliferative disorder patients, suggesting need for careful monitoring.

Extranodal involvement of the gastrointestinal tract in post transplant lymphoproliferative disorders: Stomach or small bowel involvement increases mortality risk

Discussion

Member takes

Implication

Key Points

Cite This Study

Extranodal involvement of the gastrointestinal tract in post transplant lymphoproliferative disorders: Stomach or small bowel involvement increases mortality risk

Discussion

Member takes

Implication

Key Points

Cite This Study

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