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December 8, 2025BloodOpen Access

Chronic lymphocytic leukemia mortality among u.S adults aged ≥65: A 56-year trend analysis and demographic disparities

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Authors

MAMuhammad ArhamAZAli ZubairRARana Uzair Ahmad

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Overview

Trend analysis shows CLL mortality declines in U.S. adults aged ≥65, indicating racial disparities remain significant.

Key Points

  • This research assesses long-term trends in chronic lymphocytic leukemia mortality among U.S. adults aged ≥65, highlighting demographic disparities.
  • Analyzed CLL-related mortality data from the CDC WONDER database (1968-2023).
  • Calculated age-adjusted mortality rates (AAMRs) per 100,000 population for aged ≥65.
  • Used Joinpoint regression to estimate annual percent changes (APCs) and average annual percent changes (AAPCs).
  • Stratified data by gender, ethnicity/race, age groups, and census regions.
  • Identified 175,856 CLL-related deaths among U.S. adults aged ≥65 from 1968 to 2023.
  • Mean AAMR declined from 9.3 per 100,000 in 1968 to 7.4 in 2023.
  • AAMRs were higher in males (14.1 per 100,000) compared to females (6.7 per 100,000).
  • Mortality significantly declined for females after 1999, while male mortality plateaued.
  • Racial disparities were noted, with higher AAMR in White individuals compared to Black individuals.

Cite This Study

Arham et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d1c4https://doi.org/10.1182/blood-2025-8031
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trends and disparities in mortality from chronic lymphocytic leukemia in the geriatric population in the United States from 1999 to 2020: A nationwide analysis2025
  2. 2Trends in chronic lymphocytic leukemia mortality among older adults with renal failure in the United States: A 25-year retrospective study.2025
  3. 3Trends and ARIMA-based forecast of sepsis-related mortality in chronic lymphocytic leukemia (CLL): A u.S. population-based analysis from 1999 to 20302025
  4. 4Trends in chronic lymphocytic leukemia mortality among patients with pneumonia in the United States (1999–2024): A CDC wonder database analysis2025
  5. 5Mortality trends of chronic lymphocytic leukemia and pneumonia in the United States (1999–2023): A CDC-wonder analysis2025