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December 8, 2025BloodOpen Access

Mixed autoimmune hemolytic anemia as a rare initial presentation of systemic lupus erythematosus

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Authors

MKMarina KhanEAEmeka Agudile

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Overview

Case report shows improvement in hemoglobin with immunosuppressive therapy for mixed autoimmune hemolytic anemia in SLE, suggesting a rare presentation of the disease.

Key Points

  • To highlight mixed autoimmune hemolytic anemia as a rare initial manifestation of systemic lupus erythematosus.
  • Case report of a 22-year-old Hispanic female with mixed autoimmune hemolytic anemia
  • Patient treated with immunosuppressive therapy, including prednisone and IVIG
  • Clinical and laboratory evaluations conducted throughout hospitalization
  • Patient's hemoglobin improved from 5.3 to 7.6 g/dL after treatment
  • Positive Direct Coombs Test indicated autoimmune hemolytic anemia
  • Patient met SLICC criteria for systemic lupus erythematosus during evaluation

Cite This Study

Khan et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d1a5https://doi.org/10.1182/blood-2025-6438
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Severe Warm Autoimmune Hemolytic Anemia With Profound Anemia Requiring Multimodal Immunosuppressive Therapy2026
  2. 2Autoimmune Hemolytic Anemia as an Initial Manifestation of Splenic Marginal Zone Lymphoma.2025
  3. 3Autoimmune hemolytic anemia with an initially negative direct antiglobulin test: A diagnostic challenge2025
  4. 4A Case Report of a 14-year-old Boy with Mixed-type Autoimmune Hemolytic Anemia2025
  5. 5Warm autoimmune hemolytic anemia following epstein-barr virus reactivation: An uncommon clinical association2025