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December 8, 2025Blood

Non-cancer related deaths in myeloproliferative neoplasm and Myelodysplastic Syndromes : A populaton based analysis

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Authors

CYConnor Yost

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Overview

Population-based analysis shows elevated non-cancer mortality from infectious diseases and tuberculosis in myeloproliferative neoplasm patients, suggesting urgent health interventions.

Key Points

  • To characterize leading causes of non-cancer mortality in patients with myeloproliferative neoplasm and myelodysplastic syndromes.
  • Retrospective analysis of 166,785 adults with MPN or MDS using SEER database
  • Calculated Standardized Mortality Ratios comparing observed non-cancer deaths to expected deaths
  • Stratified data by age, sex, race, ethnicity, and major categories of non-cancer causes of death.
  • 43.8% of patients had myelodysplastic syndromes; highest mortality cause was tuberculosis at SMR 7.22
  • Infections, chronic liver disease, and vascular diseases also notable causes of death
  • Elevated mortality risk noted for AI/AN individuals and younger patients due to specific conditions.

Cite This Study

Connor Yost (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d19dhttps://doi.org/10.1182/blood-2025-6416
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Two decades of infectious mortality in Myelodysplastic Syndromes: An analysis from the CDC wonder database2025
  2. 2Trends and disparities in myelodysplastic Syndrome–Associated mortality in the u.S. from 1999 to 2020: A population-based study using the CDC wonder database2025
  3. 3Cause of non-cancer related death among patients diagnosed with lymphoid neoplasm: A SEER-based study2025
  4. 4Comprehensive analysis of cancer and non-cancer mortality in patients with bone metastases: A population-based study2025
  5. 5Longitudinal trends (1999–2023) and forecasted mortality (2024–2030) in sepsis-associated mortality among patients with Myelodysplastic Syndromes in the United States.2025