December 8, 2025BloodOpen Access

Effect of immunoglobulin-replacement therapy on the incidence of severe infections in patients with chronic lymphocytic leukemia

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Authors

JZJuan ZhouDalhousie University ECElisabeth Calderón‐GómezGrifols (Spain)AAAntoine AzarJohns Hopkins University

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Implication

Retrospective cohort study demonstrated immunoglobulin-replacement therapy lowers severe infections in patients with chronic lymphocytic leukemia and hypogammaglobulinemia.

Key Points

Assess the effectiveness of immunoglobulin-replacement therapy on the incidence of severe infections in patients with CLL and hypogammaglobulinemia.
Retrospective cohort study using US insurance claims data
Included patients with chronic lymphocytic leukemia and hypogammaglobulinemia
Received >=4 doses of immunoglobulin-replacement therapy (IGIV-C10%)
Used logistic regression to analyze data
64 patients included in the analysis
83% reduction in adjusted odds of severe infections post-IGIV-C10% initiation
Statistically significant reduction in infections after therapy initiation

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d096 https://doi.org/10.1182/blood-2025-2729

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Implication

Retrospective cohort study demonstrated immunoglobulin-replacement therapy lowers severe infections in patients with chronic lymphocytic leukemia and hypogammaglobulinemia.

Effect of immunoglobulin-replacement therapy on the incidence of severe infections in patients with chronic lymphocytic leukemia

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of immunoglobulin-replacement therapy on the incidence of severe infections in patients with chronic lymphocytic leukemia

Discussion

Member takes

Implication

Key Points

Cite This Study

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