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December 8, 2025BloodOpen Access

Incidence of severe infections in patients with multiple myeloma treated with immunoglobulin-replacement therapy

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Authors

EVElisabet ViaynaJZJiani ZhouJJJames Jordan

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Overview

Retrospective analysis reveals immunoglobulin replacement therapy significantly lowers severe infection rates in multiple myeloma patients with secondary immunodeficiency.

Key Points

  • Significantly reduced odds of severe infections were observed post-IGIV-C10% treatment, suggesting its effectiveness.
  • Odds of severe infection decreased by 59% during the post-treatment period with an odds ratio of 0.41.
  • Retrospective real-world evidence analysis utilizing PharMetrics Plus claims database focused on patients with MM.
  • Regular infusion of IGIV-C10% highlights a potential therapy to combat severe infections in immunodeficient patients.

Cite This Study

Viayna et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d9d3https://doi.org/10.1182/blood-2025-4576
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