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December 8, 2025BloodOpen Access

Platelet mitofusin-1 mediates endothelial cell dysfunction in pulmonary arterial hypertension via the NLRP3 inflammasome and interleukin-1B

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Authors

AJAndrea Braganza JardiniKRKrithika Rao

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Overview

Research reveals platelet mitofusin-1 mediates endothelial dysfunction in pulmonary arterial hypertension, indicating a role for interleukin-1B signaling.

Key Points

  • This study aims to elucidate the role of platelet mitofusin-1 in endothelial cell dysfunction associated with pulmonary arterial hypertension.
  • Used human platelets from PAH patients and platelet-specific MFN1 knockout mice
  • Investigated protein levels of mitofusin-1 and its interaction with the NLRP3 inflammasome
  • Developed a co-culture model of human platelets and pulmonary artery endothelial cells
  • Platelet MFN1 levels are increased in PAH patients, promoting endothelial cell dysfunction
  • Hypoxia enhances MFN1 mRNA translation in platelets
  • Platelet secretion of interleukin-1B induces endothelial cell proliferation and activation

Cite This Study

Jardini et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236d04bhttps://doi.org/10.1182/blood-2025-422
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Also Consider

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  5. 5Pulmonary arterial hypertension from a translational perspective: Bridging pathophysiology and treatment2026