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December 8, 2025BloodOpen Access

PRMT1 drives platelet metabolic reprogramming, thromboinflammation, and antiplatelet drug resistance

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Authors

ALAnlun LiPZPeipei ZhangSLSzumam Liu

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Overview

Platelet hyperactivity and resistance to drugs affect bleeding time in conditions like diabetes, suggesting PRMT1 is a key target.

Key Points

  • This research aims to elucidate the role of PRMT1 in platelet hyperactivity and antiplatelet drug resistance.
  • Utilized megakaryocyte-specific PRMT1 overexpression and knockout mouse models for analysis.
  • Conducted thrombin-mediated platelet aggregation and tail bleeding assays.
  • Performed proteomic profiling and FACS analysis to study platelet characteristics.
  • PRMT1 enhanced platelet aggregation and shortened bleeding time in tests.
  • Knockout models showed prolonged bleeding times and reduced platelet aggregation capacity.
  • PRMT1 was found to upregulate thromboxane production, affecting platelet activity.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236d047https://doi.org/10.1182/blood-2025-418
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PRMT1-mediated metabolic reprogramming promotes leukemogenesis2025 · 2 citations
  2. 2Platelet priming in MPN triggers pro-thrombotic intermediate affinity state in αIIbβ3 integrin2025 · 1 citations
  3. 3Cytoskeletal rearrangements and SRC signalling defects controlled by PP1β drive impaired megakaryocyte maturation and platelet production2025
  4. 4Tumor necrosis factor-alpha (TNFα) drives pathologic platelet hyperreactivity through signaling on hematopoietic stem/progenitor cells and expansion of canonical megakaryocytic progenitors.2025
  5. 5Pyruvate kinase M2 promotes venous thrombosis by enhancing SNAP23-mediated platelet exocytosis and consequent NETosis2025