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December 8, 2025BloodOpen Access

Plasma cell leukemia: A single institution review of cases

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Authors

RTRicha Thakur

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Overview

Retrospective review uncovers treatment strategies impacting progression free survival in plasma cell leukemia.

Key Points

  • This review aims to evaluate treatment strategies and outcomes in patients with plasma cell leukemia at a single institution.
  • Conducted a retrospective chart review of plasma cell leukemia cases treated at Northwell Health from 2016 to 2024.
  • Analyzed patient demographics, treatment regimens, and survival outcomes including progression free survival and overall survival.
  • Defined plasma cell leukemia using the International Myeloma Working Group consensus definition.
  • Included 23 patients with a median age of 59 years; results showed poor overall survival and progression free survival rates.
  • PFS on first-line therapy was 124 days for the entire cohort, with little difference based on chemotherapy type.
  • Only 30% of patients completed autologous stem cell transplant during first-line therapy, limiting treatment options.

Cite This Study

Richa Thakur (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236d017https://doi.org/10.1182/blood-2025-8123
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Also Consider

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  1. 1Patterns of progression and clinical outcomes after first relapse in patients with primary plasma cell leukemia2025
  2. 2Outcomes of pPCL Diagnosed Using the IMWG 2021 Consensus Definition: A Retrospective Multicenter Analysis2026
  3. 3Prognostic implications of measurable residual disease and autologous hematopoietic stem cell transplantation in primary plasma cell leukemia in the era of novel agents2025
  4. 4Multiple myeloma with ≥1% circulating plasma cells in peripheral blood has a poor prognosis2025
  5. 5Durable response of primary cardiac lymphoma after autologous stem cell transplantation and sequential CAR-T therapy: a case report and literature review2025 · 4 citations