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December 8, 2025BloodOpen Access

Patterns of progression and clinical outcomes after first relapse in patients with primary plasma cell leukemia

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Authors

SKShaji KumarTHTamer HellouPKPrashant Kapoor

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Overview

Retrospective analysis reveals survival outcomes improve with venetoclax in primary plasma cell leukemia, highlighting critical clinical features.

Key Points

  • Median overall survival after first relapse in primary plasma cell leukemia is 39 months, indicating significant functional decline.
  • Patients with symptomatic relapses after initial therapy experience significantly shorter time to next treatment, at 3.9 months.
  • Observational analysis of clinical features revealed that past treatment lines greatly affect outcomes of subsequent therapies.
  • Findings suggest that novel agent-based treatments and autologous stem cell transplantation as first-line therapy do not prevent disease progression.

Cite This Study

Kumar et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d47chttps://doi.org/10.1182/blood-2025-1036
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