What question did this study set out to answer?

This study aims to evaluate the effectiveness of Area Deprivation Index (ADI) and Social Vulnerability Index (SVI) as predictors of survival in older adults with Acute Myeloid Leukemia (AML).

December 8, 2025BloodOpen Access

Area deprivation index as a predictor of survival and treatment disparities in older adults with Acute Myeloid Leukemia: A population-based Study

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Authors

VTValerie TranUniversity of Virginia APAsal PilehvariUniversity of Virginia Health System NBNadia M. BambaceBaptist Hospital of Miami

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Implication

Population-based study shows higher ADI predicts poorer survival and treatment disparities in older adults with AML, indicating social factors may impact outcomes.

Key Points

This study aims to evaluate the effectiveness of Area Deprivation Index (ADI) and Social Vulnerability Index (SVI) as predictors of survival in older adults with Acute Myeloid Leukemia (AML).
Used SEER-Medicare claims data for patients diagnosed with AML aged ≥66 years.
Linked SVI and ADI to patients' ZIP code-based geographies, using indicators for socioeconomic conditions.
Applied Kaplan-Meier and Cox proportional hazards models to assess survival and treatment outcomes.
High ADI was significantly associated with worse overall survival in older AML patients (median survival: 2 months vs 4 months for low ADI).
Chemotherapy use was lower in high ADI and high SVI groups among survivors (p=0.012 and p=0.007).
Bone marrow transplant use was less common in high ADI compared to low ADI (11.5% vs 15.2%; p=0.003).
High ADI linked to increased hospice use in the last 3 months of life (p<0.001).

Cite This Study

Tran et al. (2025) studied this question.

synapsesocial.com/papers/693624ce4fa91c937236cf89 https://doi.org/10.1182/blood-2025-2847

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Implication

Population-based study shows higher ADI predicts poorer survival and treatment disparities in older adults with AML, indicating social factors may impact outcomes.

Area deprivation index as a predictor of survival and treatment disparities in older adults with Acute Myeloid Leukemia: A population-based Study

Discussion

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Implication

Key Points

Cite This Study

Area deprivation index as a predictor of survival and treatment disparities in older adults with Acute Myeloid Leukemia: A population-based Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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