Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Cardiovascular MedicineOpen Access

Mechanisms Involved in the Adverse Cardiovascular Effects of Selective Cyclooxygenase-2 Inhibitors

View Full Paper
Ask AI
Bookmark
Share

Authors

ALAsela Berenice López-Cuellar

Discussion

Loading...

Member takes

Overview

Review explores how selective COX-2 inhibitors increase cardiovascular risks through thrombosis and inflammation pathways.

Key Points

  • This review aims to elucidate the mechanisms by which selective COX-2 inhibitors contribute to cardiovascular complications.
  • Reviewed pathophysiological mechanisms of COX-2 inhibitors.
  • Analyzed the imbalance between prothrombotic and antithrombotic factors.
  • Investigated the role of genetic polymorphisms and matrix metalloproteinases in cardiovascular risk.
  • COX-2 inhibition disrupts renal prostaglandin synthesis, increasing thrombosis risk.
  • Altered endocannabinoid metabolism and PPARδ downregulation promote fluid retention and vasoconstriction.
  • COX-2 inhibitors are associated with myocardial injury, cardiac fibrosis, and increased arterial pressure.

Cite This Study

Asela Berenice López-Cuellar (2025) studied this question.

synapsesocial.com/papers/693624ce4fa91c937236cd94https://doi.org/10.3390/cardiovascmed28010005
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anti-Inflammatory Mechanisms of Selective Cox-2 Inhibitors: A Preclinical Analysis2025
  2. 2Fibroblast Cyclo‐Oxygenase‐2 Associated With the Kidney Restrains Methylarginines and Thrombosis: Relevance to Cardiovascular Side Effects of Non‐Steroidal Anti‐Inflammatory Drugs2025
  3. 3Recent Advances in the Therapeutic Prospective of Heterocyclic Derivatives as COX-2 Inhibitors (2019-Present)2025
  4. 4Lipid Raft Membrane Interactivity Correlating with Cyclooxygenase-2 Selectivity of Non-Steroidal Anti-Inflammatory Drugs2025
  5. 5Role of Selective Cyclooxygenase-2 Inhibitors in Renal Colic Pain Reduction and Improvement: A Systematic Review of Clinical Trials2023