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September 5, 2025The FASEB JournalOpen Access

Fibroblast Cyclo‐Oxygenase‐2 Associated With the Kidney Restrains Methylarginines and Thrombosis: Relevance to Cardiovascular Side Effects of Non‐Steroidal Anti‐Inflammatory Drugs

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Authors

MPMaria Elisa Lopes PiresFSFisnik ShalaUSUgo Soffientini

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Overview

Observational analysis found fibroblast cyclo-oxygenase-2 contributes to methylarginines and increased thrombosis in mice, suggesting essential renal pathways to consider.

Key Points

  • Deletion of fibroblast cyclo-oxygenase-2 increased thrombosis risk after arterial injury, impacting cardiovascular health.
  • Knockout models indicated a direct link between methylarginines and systemic endothelial dysfunction in the absence of cyclo-oxygenase-2.
  • Generated mouse models allowed for precise examination of renal cyclo-oxygenase-2 pathways related to NSAID-induced risks.
  • Use of L-arginine reversed pro-thrombotic phenotypes in knockout mice, indicating its potential therapeutic role.

Cite This Study

Pires et al. (2025) studied this question.

synapsesocial.com/papers/68c238d2b210217d64779d0ehttps://doi.org/10.1096/fj.202501900r
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Also Consider

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  1. 1Anti-Inflammatory Mechanisms of Selective Cox-2 Inhibitors: A Preclinical Analysis2025
  2. 2Recent Advances in the Therapeutic Prospective of Heterocyclic Derivatives as COX-2 Inhibitors (2019-Present)2025
  3. 3Lipid Raft Membrane Interactivity Correlating with Cyclooxygenase-2 Selectivity of Non-Steroidal Anti-Inflammatory Drugs2025
  4. 4Transition Between Healthy Aging and Renal Dysfunction During Natural Aging: Role Of p21, p16, NADPH Oxidase, NFkB, and COX-22025
  5. 5Sympathetic Activation Promotes Kidney Fibrosis in Mice via Macrophage‐Derived N2ICD‐Enriched Extracellular Vesicles2025 · 3 citations