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December 8, 2025Journal of Nuclear MedicineOpen Access

Dynamic Acquisition of 99m TcTc-Pyrophosphate SPECT/CT Images in Transthyretin Cardiac Amyloidosis: A Pilot Study

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Authors

AMAlyssa De MoraesMKMarie Foley KijewskiSCSarah Cuddy

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Overview

Pilot study shows dynamic imaging improves detection of cardiac amyloidosis, indicating timing of peak uptake matters.

Key Points

  • This research aims to determine the timing of peak Tc-pyrophosphate uptake in transthyretin cardiac amyloidosis.
  • Dynamic SPECT/CT images were acquired at multiple time points after injection.
  • Image analysis involved both visual assessment and quantitative metrics like SUVmean and SUVmax.
  • Cohorts of participants with and without transthyretin amyloid cardiomyopathy were compared.
  • In ATTR-CM patients, myocardial SUVmean was significantly higher at 10 minutes compared to the blood pool.
  • Myocardial SUVmean decreased from 3.86 at 10 min to 2.88 at 150 min in ATTR-CM patients.
  • The non-ATTR-CM group showed stable myocardial SUVmean across all time points.

Cite This Study

Moraes et al. (2025) studied this question.

synapsesocial.com/papers/693624ce4fa91c937236cd74https://doi.org/10.2967/jnumed.125.270405
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early timepoint 99mTc-DPD whole body scintigraphy and quantitative SPECT/CT imaging for diagnosis of cardiac ATTR amyloidosis2026
  2. 2Differentiation and correlation of regional uptake heterogeneity with cardiac dysfunction in biopsy-proven transthyretin amyloid cardiomyopathy using quantitative single-photon emission computed tomography/computed tomography: a single-center, cross-sectional study2025 · 2 citations
  3. 3Pathology-Based Validation of Quantitative SPECT/CT in Patients With Suspected Transthyretin Amyloid Cardiomyopathy2026
  4. 4Elucidating associations between technetium pyrophosphate scintigraphy, echocardiography and cardiac biomarkers in transthyretin cardiac amyloidosis2025 · 1 citations
  5. 5Electrocardiographic Features in Transthyretin Cardiac Amyloidosis2025