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September 10, 2025EJNMMI ResearchOpen Access

Differentiation and correlation of regional uptake heterogeneity with cardiac dysfunction in biopsy-proven transthyretin amyloid cardiomyopathy using quantitative single-photon emission computed tomography/computed tomography: a single-center, cross-sectional study

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Authors

MTMasakazu TsujimotoFujita Health UniversityHKHideki KawaiFujita Health UniversitySTShingo TanahashiFujita Health University Hospital

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Implication

Cross-sectional study evaluates uptake heterogeneity and its correlation with cardiac dysfunction in patients with transthyretin amyloid cardiomyopathy, suggesting new diagnostic approaches.

Key Points

  • Local uptake heterogeneity correlates significantly with indicators of cardiac dysfunction, indicating disease severity.
  • The heart-to-aorta ratio effectively differentiates patients with transthyretin amyloid cardiomyopathy from other amyloidosis types.
  • Quantitative analysis using SPECT/CT provides critical insights into the extent of cardiac amyloidosis, aiding in diagnosis.
  • Standardized uptake value metrics highlight the relationship between myocardial uptake variation and cardiac function impairment.

Cite This Study

Tsujimoto et al. (2025) studied this question.

synapsesocial.com/papers/68c23f63b210217d647962f0https://doi.org/10.1186/s13550-025-01292-w
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  1. 1Cardiac Scintigraphy With Technetium-99m-Labeled Bone-Seeking Tracers for Suspected Amyloidosis2020 · 255 citations