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December 8, 2025Journal of Pineal ResearchOpen Access

Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications

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Authors

ŁKŁukasz Konecki

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Overview

Review reveals melatonin's anticancer effects in gastrointestinal cancers, indicating its potential as an adjuvant treatment.

Key Points

  • This review aims to synthesize evidence on the therapeutic potential of melatonin in gastrointestinal cancers.
  • Reviewed preclinical and clinical evidence of melatonin's effects on GI cancers
  • Examined molecular mechanisms like NF‐κB and PI3K/AKT pathways
  • Analyzed clinical trial outcomes regarding melatonin supplementation in shift workers
  • Melatonin reduced tumor volume by 70% in murine colorectal models
  • 23%–41% risk reduction in colorectal cancer with melatonin supplementation
  • 53% decrease in radiotherapy-induced oral mucositis

Cite This Study

Łukasz Konecki (2025) studied this question.

synapsesocial.com/papers/693624ba4fa91c937236c7e2https://doi.org/10.1111/jpi.70101
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