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December 8, 2025British journal of surgeryOpen Access

Major systemic infection following breast cancer surgery and oncological outcomes

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Authors

LALinda AdwallIFIrma FredrikssonHHHella Hultin

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Overview

Nationwide cohort study reports increased distant recurrence risk in breast cancer patients post-infection, suggesting need for management.

Key Points

  • The study aims to evaluate the impact of major systemic infections on breast cancer recurrence and survival.
  • Nationwide cohort study of breast cancer patients in Sweden (2008-2019)
  • Identified patients using BCBaSe 3.0 database
  • Primary exposure was major systemic infection within 90 days of surgery
  • Analyses included secondary evaluations of stroke, myocardial infarction, and pulmonary embolism.
  • 1.8% of patients experienced major systemic infection post-surgery
  • Major systemic infection linked to a 23% increased risk of distant recurrence (HR 1.23)
  • Overall death risk increased by 47% (HR 1.47)
  • Breast cancer-specific death risk increased by 27% (HR 1.27)

Cite This Study

Adwall et al. (2025) studied this question.

synapsesocial.com/papers/693624ad4fa91c937236c73ahttps://doi.org/10.1093/bjs/znaf233
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Major systemic infection following breast cancer surgery associated with worse oncological outcomes2025
  2. 2The impact of antibiotic prophylaxis on postoperative infections in breast cancer surgery – a retrospective quality assessment2025
  3. 3Impact of postoperative complications and type 2 diabetes on breast cancer recurrence and mortality2025 · 1 citations
  4. 4Post-Recurrence-Survival After Treatment in Breast Cancer Patients: Identifying Associated Factors2025
  5. 5The incidence and risk factors of sepsis following ovarian cancer surgery: A retrospective Nationwide Inpatient Sample database study2026