Prospective cohort identifies that PNPLA3 I148M genotype relates to tumor differentiation in MASLD patients, suggesting a role in tumor progression.
The PNPLA3 I148M GG genotype was not significantly associated with increased HCC occurrence in Korean MASLD patients within the present cohort. Although the GG genotype is known to play a role in development and progression of MASLD, further studies are warranted to clarify its contribution to tumor initiation and dedifferentiation.
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Yang et al. (2025) studied this question.
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