Contribution of PNPLA3, GCKR, MBOAT7, NCAN, and TM6SF2 Genetic Variants to Hepatocellular Carcinoma Development in Mexican Patients

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Increased risk of hepatocellular carcinoma found with specific genetic variants in Mexican individuals.
PNPLA3 genotypes showed about two-fold higher risk for hepatocellular carcinoma (OR = 2.2).
Utilized case-control study design with logistic regression to analyze genetic associations.
Findings highlight potential predictive markers for liver cancer in diverse populations.

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Case-control study shows significant links between PNPLA3, GCKR, MBOAT7 variants and increased HCC risk.

Francisco‐Cruz et al. (2025) studied this question.

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