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December 8, 2025Blood

Refining the prognostic hierarchy of TP53 multihit alterations and isolated deletion of chromosome 5q in myelodysplastic syndromes

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Authors

MMMaría Julia MontoroPAPamela AchaBXBlanca Xicoy

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Overview

Multicenter analysis demonstrates implications of lower-risk TP53 multihit status on survival in myelodysplastic syndromes.

Key Points

  • To refine the prognostic hierarchy of TP53 multihit alterations in MDS with isolated 5q deletion.
  • Retrospective international cohort study of MDS patients
  • Comparison of clinical and genetic features of MDS-del(5q) and MDS-LB with TP53 multihit
  • Assessment of overall survival and AML progression using IPSS-R and IPSS-M scoring.
  • MDS-del(5q) TP53 multihit patients showed higher platelet counts compared to MDS-LB TP53 multihit patients.
  • Median overall survival for MDS-del(5q) TP53 multihit was 57 months, significantly longer than 14 months for MDS-LB TP53 multihit.
  • MDS-del(5q) TP53 multihit patients demonstrated a longer median time to AML progression compared to MDS-LB TP53 multihit.

Cite This Study

Montoro et al. (2025) studied this question.

synapsesocial.com/papers/693624984fa91c937236bfeehttps://doi.org/10.1182/blood-2025-2068
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Biallelic TP53 aberrations and double TP53 mutations are prevalent in AML/MDS patients with del(5q) complex karyotype - an NCI myelomatch and SWOG report2025 · 2 citations
  2. 2Clinical implications of TP53 mutations (TP53MT) in patients (pts) with higher risk Myelodysplastic Syndromes (HR-MDS) treated with hypomethylating agents (HMA) and allogeneic hematopoietic transplantation (allo-HCT): An analysis from the international consortium of MDS (icMDS) validate database2025
  3. 3Biallelic TP53 alterations predict poorer survival in Mantle Cell Lymphoma: Insights from a national real-world cohort high-touch project2025
  4. 4Multi-hit TP53 mutation is an independent adverse prognostic factor in allogeneic hematopoietic stem cell transplantation for acute leukemia and myelodysplastic syndromes2025
  5. 5Real-world clinical characteristics and outcomes of patients with myelodysplastic syndrome with TP53 mutation2025