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December 6, 2025JAC-Antimicrobial ResistanceOpen Access

P58 Drug resistance of Mycobacterium tuberculosis isolated from bone tissue of patients with tuberculous spondylitis and coinfections of HIV/HCV: identification of a high-risk group for MDR TB

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LLLeonid Lavrenchuk

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Overview

Analysis reveals drug resistance in Mycobacterium tuberculosis among patients with HIV and HCV, suggesting a high-risk group for MDR TB.

Key Points

  • Drug resistance significantly correlates with HIV status, increasing risk for MDR Mycobacterium tuberculosis.
  • Molecular diagnostics identified resistance-related mutations in more than 79% of strains, particularly rpoB and katG mutations.
  • Analysis included 300 patients, with PCR detecting Mycobacterium tuberculosis DNA in 83% of bone samples, outperforming standard methods.
  • Findings highlight the importance of molecular diagnostics for personalized therapy in tuberculosis patients with HIV/HCV coinfections.

Cite This Study

Leonid Lavrenchuk (2025) studied this question.

synapsesocial.com/papers/69337d09b3f947a0a125ac67https://doi.org/10.1093/jacamr/dlaf230.065
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