Incidence and detection of M.tb multi-drug resistance in Hyderabad population using the PCR–sequence method

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Prospective hospital-based study uncovers multi-drug resistance in tuberculosis patients, indicating urgent public health concern.

67.5% of non-responders had mutations in the rpoB and katG genes linked to drug resistance.
A novel mutation was identified that involves an extra Arginine at codon 513 in the M.tb strain.
PCR-sequencing successfully identified mutations, enhancing sensitivity in drug susceptibility screening.
The findings highlight the rising threat of multi-drug resistant tuberculosis strains in the Hyderabad population.

Basith et al. (2025) studied this question.

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View Full Paper

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Authors

Prospective hospital-based study uncovers multi-drug resistance in tuberculosis patients, indicating urgent public health concern.

67.5% of non-responders had mutations in the rpoB and katG genes linked to drug resistance.
A novel mutation was identified that involves an extra Arginine at codon 513 in the M.tb strain.
PCR-sequencing successfully identified mutations, enhancing sensitivity in drug susceptibility screening.
The findings highlight the rising threat of multi-drug resistant tuberculosis strains in the Hyderabad population.

Basith et al. (2025) studied this question.

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