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December 6, 2025CancersOpen Access

Towards a New Standard: Prospective Validation of Ex Vivo Fusion Confocal Microscopy for Intraoperative Margin Assessment in Breast-Conserving Cancer Surgery

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Authors

LBLidia BlayKMKarol Matute-MolinaPFPedro L. Fernández

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Overview

Observational analysis shows high diagnostic accuracy for breast-conserving surgery, indicating potential to reduce re-excisions.

Key Points

  • The ex vivo fusion confocal microscopy achieved over 93% diagnostic accuracy for tumour detection and classification, ensuring precise intraoperative margin assessments for breast cancers.
  • Almost perfect interobserver agreement of 97.3% was observed for neoplasia detection and 93.8% for tumour type classification among the evaluating pathologists.
  • A prospective observational diagnostic validation study was undertaken with 144 breast tissue specimens stained with acridine orange for imaging accuracy assessment during surgeries.
  • Integration of EVFCM could enhance oncological safety by minimizing local recurrence rates and improving patient outcomes post-surgery.

Cite This Study

Blay et al. (2025) studied this question.

synapsesocial.com/papers/69337cfbb3f947a0a125a65ehttps://doi.org/10.3390/cancers17233848
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluating Ex Vivo Fluorescence Confocal Microscopy for Intraoperative Diagnosis in Pediatric Surgery: A Feasibility Study2025 · 3 citations
  2. 2Diagnostic Accuracy of Ex Vivo Confocal Microscopy for Surgical Margin Assessment of High-Risk Nodular Basal Cell Carcinoma2025
  3. 3Confocal fluorescence microscopy for real-time breast cancer diagnosis: current advances and future perspectives2025
  4. 4Confocal Microscopy for Intraoperative Margin Assessment of Lumpectomies by Surgeons in Breast Cancer: Training, Implementation in Routine Practice, and Two-Year Retrospective Analysis2025 · 1 citations
  5. 5Image-guided real-time optical biopsy in oncologic surgery: a systematic review of the role of confocal microscopy in the era of digital surgery2025