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September 10, 2025European Journal of Pediatric Surgery

Evaluating Ex Vivo Fluorescence Confocal Microscopy for Intraoperative Diagnosis in Pediatric Surgery: A Feasibility Study

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Authors

DFDonatella Di FabrizioFMFrancesca MastrobertiITIrene Tavolario

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Overview

Feasibility study demonstrates FCM achieves 100% sensitivity in pediatric patients, suggesting it can enhance histological evaluations.

Key Points

  • FCM achieved 100% sensitivity and 87.5% specificity in diagnosing tissue samples, outperforming conventional methods.
  • Interobserver agreement for FCM was perfect with a Cohen's kappa coefficient of 1.00, indicating strong reliability.
  • This observational analysis involved 18 pediatric tissue samples, comparing FCM to conventional histology for diagnosis.
  • FCM's rapid results could improve intraoperative decision-making in pediatric surgeries, but further studies are needed.

Cite This Study

Fabrizio et al. (2025) studied this question.

synapsesocial.com/papers/68c241efb210217d647a1ffahttps://doi.org/10.1055/a-2676-2999
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