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December 5, 2025Journal of the American Heart AssociationOpen Access

Sex‐Based Differences in Long‐Term Outcomes of Patients With Ascending Aortic Dilation

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Authors

MAMohammed AbusafiaSJShada JadamVKVidyasagar Kalahasti

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Overview

Analysis shows worse long-term outcomes in women after surgery for ascending aortic dilation, indicating potential need for revised surgical criteria.

Key Points

  • Long-term outcomes reveal worse survival in women with ascending aortic dilation when compared to men.
  • Among 14,244 patients with unrepaired aortic dilation, 26.1% underwent surgery within 0.86 years, with women having higher surgical rates.
  • Cox proportional hazards and Kaplan–Meier survival analysis demonstrate independent associations between female sex and increased mortality rates.
  • Despite fewer comorbidities, the significant mortality rate among women suggests a reevaluation of surgical thresholds for ascending aortic dilation.

Cite This Study

Abusafia et al. (2025) studied this question.

synapsesocial.com/papers/693231368e51979591dcebbfhttps://doi.org/10.1161/jaha.125.045827
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sex-Related Differences in Histopathology and Hormonal Associations in Ascending Aortic Aneurysms2026
  2. 2Long-Term Outcomes in Aortic Stenosis: Mortality Analysis in a Selected Patient Group2025 · 1 citations
  3. 3Sex-Based Differences in Outcomes Following Endovascular Repair of Unruptured Abdominal Aortic Aneurysms by Size2026
  4. 4A comparison of women and men with small abdominal aortic aneurysms2025 · 1 citations
  5. 5Gender variations in acute aortic dissection: insights from a retrospective cohort analysis2025