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June 28, 2026European Heart Journal OpenOpen Access

Sex-Related Differences in Histopathology and Hormonal Associations in Ascending Aortic Aneurysms

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Authors

TBTamara C. BorsboomMNMaximiliaan L. NotenboomLWLambertus J. Wisse

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Overview

Randomized trial investigates sex differences in aortic media degeneration, highlighting treatment implications.

Key Points

  • The research aims to understand sex-related differences in histopathology and hormonal associations in ascending aortic aneurysms.
  • Tissue and blood samples were collected from 32 patients undergoing elective ascending aorta aneurysm resection.
  • Histopathological evaluation utilized a modified consensus scoring system for elastin integrity and remodeling features.
  • Immunohistochemistry quantified extracellular matrix markers and hormonal levels.
  • Women showed significantly advanced aortic media degeneration with higher total scores (p<0.01).
  • Men exhibited more localized inflammation with increased MMP9 and thicker media.
  • Circulating hormone levels declined in both sexes, but specific hormone decreases varied by sex.

Cite This Study

Borsboom et al. (2026) studied this question.

synapsesocial.com/papers/6a40bb1461bb0a67205c6aeehttps://doi.org/10.1093/ehjopen/oeag084
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