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December 5, 2025Journal of Liver CancerOpen Access

Re-evaluating DAA therapy in active hepatocellular carcinoma: from controversy to clinical considerations

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Cohort studies reveal potential safety of DAA therapy in HCC, suggesting need for individualized management strategies.

DAA therapy shows safety in active hepatocellular carcinoma management with no clear harm.
Cohort studies report findings are mostly neutral regarding HCC recurrence and oncologic outcomes.
Observational analysis across diverse studies highlights the necessity for multidisciplinary decisions in HCC treatment.
Prospective studies are essential for establishing guidelines on DAA therapy and its impact on tumor biology.

Jeon et al. (2025) studied this question.

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