Unveiling the nexus between direct-acting antivirals in hepatitis C virus elimination and immune response

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Review highlights the impact of direct-acting antivirals on immune response and T cell exhaustion in hepatitis C.

Direct-acting antivirals significantly improve sustained virological response rates in hepatitis C patients.
T cell exhaustion is a critical barrier to effective immune response and HCV clearance.
DAA therapy influences CD8+ and CD4+ T cell responses, potentially affecting chronic infection outcomes.
Understanding DAA therapy's effects on the immune system may lead to more effective hepatitis C control strategies.

Abdelaziz et al. (2025) studied this question.

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