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December 4, 2025Diabetology & Metabolic SyndromeOpen Access

Honokiol attenuates diabetic nephropathy by targeting SIRT3 to suppress mitochondrial ROS-induced pyroptosis

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Authors

KYKe YuMLMaodong LiuTZTao Zhang

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Overview

Observational analysis reveals Honokiol improves renal function in diabetic nephropathy, indicating its role in SIRT3 and mitochondrial ROS regulation.

Key Points

  • Honokiol treatment significantly improves renal dysfunction and mitochondrial function in diabetic nephropathy.
  • HKL upregulates SIRT3, suppressing pyroptosis and mitochondrial ROS accumulation in db/db diabetic mice.
  • The study used biochemical assays and immunofluorescence staining to assess therapeutic effects on renal function.
  • This renoprotective strategy supports targeting mitochondrial dysfunction to combat diabetic nephropathy.

Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/6930e8e3ea1aef094cca3f0ahttps://doi.org/10.1186/s13098-025-02045-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effects of Honokiol on the liver of Alzheimer's disease mice by upregulating SIRT3.2025
  2. 2Dihydromikanolide Inhibits <scp>ROS</scp>‐Mediated <scp>NLRP3</scp> Inflammation via Antioxidant Nrf2 Activation and Mitophagy Induction in <scp>LPS</scp>/<scp>ATP</scp>‐Stimulated Macrophages2025
  3. 3Sirtuin 3 in diabetic kidney disease: mechanisms and pharmacotherapy2025
  4. 4The protective effect of kaempferol on high glucose-stimulated renal tubular epithelial cells2025
  5. 5Knockdown of SHP-2 delays renal tubular epithelial cell injury in diabetic nephropathy by inhibiting NLRP3 inflammasome-mediated pyroptosis2025