December 4, 2025VirusesOpen Access

Emergence and Pathogenicity of a Novel Goose Adenovirus Type 4 Strain JA2485: Insights for Poultry Disease Control

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Novel strain ja2485 shows significant pathogenicity with 50% mortality in Sanhua geese, highlighting transmission pathways and genetic evolution.

Pathogenicity tests indicated 50% mortality in 1-day-old Sanhua geese, and viral loads peaked in the liver, duodenum, and cloacal swabs.
Whole-genome sequencing confirmed the strain ja2485's 43,030 base pairs and identified multiple protein-coding regions relevant to disease.
Phylogenetic analysis linked strain ja2485 closely to Hungarian and Chinese strains, suggesting significant genetic evolution within GoAdV-4.
Further insights into pathogenic mechanisms inform targeted prevention strategies against goose adenovirus infections.

Gao et al. (2025) studied this question.

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Novel strain ja2485 shows significant pathogenicity with 50% mortality in Sanhua geese, highlighting transmission pathways and genetic evolution.