October 2, 2025Veterinary SciencesOpen Access

AGXT-Driven Bile Acid Dysregulation Triggers Viral Gout in Astrovirus-Infected Jiangnan White Geese

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SFSuyu FanTongji University XHXuming HuYangzhou University WCWenxian ChaiJiangsu University

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Implication

Analysis reveals GAstV infection correlates with bile acid dysregulation and hyperuricemia, highlighting AGXT's role in gout pathology in Jiangnan white geese.

Key Points

Viral gout occurred in GAstV-infected geese alongside multi-organ damage, indicating severe health impacts.
Transcriptomic sequencing identified 342 differentially expressed genes in infected kidneys, including notable upregulation of AGXT.
Study assessed gene expression and metabolic pathways to link bile acid metabolism with uric acid regulation, contributing to gout.
Findings suggest AGXT is a target for breeding strategies to combat GAstV-related metabolic disorders in waterfowl.

Cite This Study

Fan et al. (2025) studied this question.

synapsesocial.com/papers/68de5da783cbc991d0a20e07 https://doi.org/10.3390/vetsci12100951

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Implication

Analysis reveals GAstV infection correlates with bile acid dysregulation and hyperuricemia, highlighting AGXT's role in gout pathology in Jiangnan white geese.

AGXT-Driven Bile Acid Dysregulation Triggers Viral Gout in Astrovirus-Infected Jiangnan White Geese

Discussion

Member takes

Implication

Key Points

Cite This Study

AGXT-Driven Bile Acid Dysregulation Triggers Viral Gout in Astrovirus-Infected Jiangnan White Geese

Discussion

Member takes

Implication

Key Points

Cite This Study

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