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December 4, 2025Pharmacognosy MagazineOpen Access

Matairesinol Shows Neuroprotective Activity Against Cerebral Ischemia/Reperfusion Injury via Downregulating TLR4-NLRP3 Inflammasome Pathway

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Authors

HZHongyan ZhangKZKun Zhang

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Overview

In vivo analysis demonstrates that matairesinol reduces brain edema and inflammatory cytokines in ischemic stroke, suggesting therapeutic potential.

Key Points

  • Matairesinol significantly reduces brain edema and neurological scores in ischemic stroke models, indicating its neuroprotective activity.
  • Treatment with matairesinol led to lower pro-inflammatory cytokine levels and improved antioxidant concentrations in MCAO-induced rats.
  • Assessment using models of ischemic stroke and human neuroblastoma cells clarified the effects of matairesinol on inflammation and cell viability.
  • Findings highlight the need for further validation of matairesinol as a potential treatment for cerebral ischemia and reperfusion injury.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/6930dc78ea1aef094cca2392https://doi.org/10.1177/09731296251396330
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Also Consider

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  1. 1Modulatory Potential of Alpinetin on Inflammation, Oxidative Stress, Apoptosis, and Mitochondrial Dynamics in a Rat Middle Cerebral Artery Occlusion Model of Ischemic Stroke2025
  2. 220(<i>R</i>)‐ginsenoside Rg3 Inhibits Neuroinflammation Induced by Cerebral Ischemia/Reperfusion Injury by Regulating the Toll‐Like Receptor 4/Myeloid Differentiation Factor‐88/Nuclear Factor Kappa B Signaling Pathway2025
  3. 3Cardio- and neuroprotective effects by pretreatment of dietary moringin from <i>Moringa oleifera</i> seeds and α-CD/moringin formulation in a rat model of isoproterenol-induced myocardial infarction2025
  4. 4Sabinene confers protection against cerebral ischemia in rats: potential roles of antioxidants, anti-inflammatory effects, and astrocyte-neurotrophic support2025
  5. 5Time-dependent expression of neural oxidative and inflammatory biomarkers in ischemic stroke using a transient MCAO rat model2025