December 4, 2025Biotechnology and Applied Biochemistry

Gentamicin‐Loaded Chitosan Nanocoating on Polyurethane Prostatic Stents to Combat Biofilm Formation and Urogenital Device‐Associated Infections

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Authors

PVPalaniyandi Velusamy SGSubash C. B. Gopinath

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Implication

This investigation demonstrates increased antimicrobial efficacy against E. coli and biofilm formation in polyurethane prostatic stents with gentamicin-loaded chitosan nanoparticles.

Key Points

Prolonged microbial growth is reduced by gentamicin-loaded chitosan nanoparticles immobilized onto polyurethane stents, significantly limiting infections.
Nanoparticles with a size range of 200–350 nm showed 92.32% drug encapsulation efficiency, enhancing their effectiveness against pathogens.
The antimicrobial efficacy evaluation used bacterial viability assays and biofilm inhibition studies, showcasing promising results against E. coli and P. mirabilis.
The findings support the sustained release of gentamicin, indicating a significant improvement in device performance and infection prevention.

Cite This Study

Velusamy et al. (2025) studied this question.

synapsesocial.com/papers/6930dc78ea1aef094cca22ad https://doi.org/10.1002/bab.70104

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Implication

This investigation demonstrates increased antimicrobial efficacy against E. coli and biofilm formation in polyurethane prostatic stents with gentamicin-loaded chitosan nanoparticles.

Gentamicin‐Loaded Chitosan Nanocoating on Polyurethane Prostatic Stents to Combat Biofilm Formation and Urogenital Device‐Associated Infections

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Key Points

Cite This Study

Gentamicin‐Loaded Chitosan Nanocoating on Polyurethane Prostatic Stents to Combat Biofilm Formation and Urogenital Device‐Associated Infections

Discussion

Member takes

Implication

Key Points

Cite This Study

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