September 16, 2025Biomaterials ScienceOpen Access

Dual-Action Prevention of Adherent and Non-Adherent Biofouling via Slippery, Nitric Oxide-Releasing Nanoemulsion-Infused Porous Surfaces

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The infused ePTFE maintained slippery behavior while delivering nitric oxide for 24 hours.
It significantly reduced S. aureus and E. coli adhesion, improving infection resistance in medical devices.
The material exhibited cytocompatibility with cell viability above 70%, enhancing safety for biomedical applications.
Absence of hemolytic effects when exposed to dilute whole blood indicates potential for safe use in critical care.

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This approach combines slippery surfaces with nitric oxide delivery to reduce biofouling and infection risks.

Nguyen et al. (2025) studied this question.

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