Isolation of 13‐residue peptaibiotics from marine‐derived fungus Acremonium persicinum and their underlying antifungal mechanisms against Botrytis cinerea

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Bioassay reveals peptaibiotics improve spore germination inhibition in Botrytis cinerea, indicating new antifungal strategies.

Peptaibiotics isolated from Acremonium persicinum inhibited spore germination of Botrytis cinerea.
The most bioactive adenopeptin disrupted mitochondrial integrity and caused cell damage, affecting fungi viability.
Bioassay-guided isolation identified effective peptaibiotics with potential in antifungal applications against resistance.
Study highlights challenges posed by fungicide resistance, indicating new antifungal options from fungal metabolites.

Li et al. (2025) studied this question.

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