The Antifungal Ability of Amino Acid Substitution of Antimicrobial Peptide Epinecidin-1 to Botrytis cinerea in Peach Fruit

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Observational analysis shows EPI-4 reduced postharvest gray mold in peaches, suggesting enhanced antifungal properties of EPI analogues.

EPI-4 effectively controlled postharvest gray mold, outperforming regular EPI in peach fruit.
Among the EPI analogues, EPI-4 showed the highest anti-B. cinerea activity with a MIC value of 6 μmol/L.
EPI-4 reduced cytotoxicity and enhanced the DNA binding ability of B. cinerea by twofold during in vitro experiments.
These findings suggest that EPI-4 has strong potential for regulating gray mold disease in postharvest management.

Fan et al. (2025) studied this question.

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