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December 4, 2025Biotechnology and Applied BiochemistryOpen Access

Transient Transfection of Rolling‐Circle Amplified DNA in Biomanufacturing‐Relevant Mammalian Cell Lines: A Comparison of Transfection Conditions for Optimal Protein Expression

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Authors

ELEvelina LoghinNHNathan E. Hudson

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Overview

Comparative analysis reveals cationic polymer enhances transfection efficiency for monoclonal antibodies in CHO cells, suggesting new biopharmaceutical methods.

Key Points

  • Transfection of monoclonal antibodies achieved high efficiency using cationic polymer with CHO cells.
  • Analysis showed enhancing expression by 30% with cationic polymer-based transfection under controlled conditions.
  • Evaluation of transfection conditions across different cell lines identified optimal blends for RCA DNA delivery.
  • Findings highlight potential for improved biopharmaceutical manufacturing using large synthetic DNA alternatives.

Cite This Study

Loghin et al. (2025) studied this question.

synapsesocial.com/papers/6930dc5fea1aef094cca1debhttps://doi.org/10.1002/bab.70100
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rolling circle amplification for next-generation molecular diagnostics, genome analysis, and spatial transcriptome profiling2025
  2. 2Autonomous Exponential Amplification via Rolling Circle–DNAzyme Feedback Programming2025
  3. 3Structural and Kinetic Profiling of Rolling Circle Amplification via Solid-State Nanopore Sensing Using miR-21 as a Model2025
  4. 4Rolling Circle Amplification Boosts Ultrasensitive Liquid Biopsy.2025
  5. 5Rolling Circle Amplification as a Molecular Tool for Spatially Resolved Signal Amplification in Single Molecule Counting Assay2025