November 30, 2025The Chemical RecordOpen Access

Thiazolotriazoles: Their Biological Activity and Structure–Activity Relationships

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Thiazolotriazoles demonstrate significant antibacterial and anticancer properties for drug discovery, indicating their therapeutic potential.
Key activities include analgesic, antidibetic, anti-inflammatory, and antioxidant effects related to their biological activity.
Synthesis is achieved through diverse methods, including enzyme inhibition for key targets: carbonic anhydrase and butyrylcholinesterase.
Understanding the structure–activity relationship of thiazolotriazoles may guide the design of new bioactive compounds and therapies.

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This review uncovers the biological activity and drug targets of thiazolotriazoles, highlighting their potential in drug discovery.

Purakkel et al. (2025) studied this question.

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