September 10, 2025OrganicsOpen Access

Synthesis and Biological Activity of 5-Substituted-2,4-dihydro-1,2,4-triazole-3-thiones and Their Derivatives

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Compounds derived from 1,2,4-triazole-3-thione exhibit various biological activities, including antimicrobial effects.
Key derivatives showed up to 96% yield during synthesis, displaying effective methods for obtaining active compounds.
The presence of certain electron-donating groups enhances biological activity across multiple target applications.
1,2,4-triazole-3-thione derivatives demonstrate significant potential for drug and agrochemical development.

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Study demonstrates high antimicrobial and antitumor activity in 1,2,4-triazole-3-thione derivatives, indicating drug potential.

Ziyaev et al. (2025) studied this question.

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