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September 10, 2025Scientific ReportsOpen Access

Identification and experimental validation of mitochondrial and endoplasmic reticulum stress related gene in diabetic nephropathy

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Authors

TLTao LiLLLi LiZSZeao Sun

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Overview

This research identifies key mitochondrial and ER stress genes in diabetic nephropathy, suggesting potential therapeutic implications.

Key Points

  • Three key genes related to mitochondrial and endoplasmic reticulum stress were identified in diabetic nephropathy.
  • The genes GPX1, PPIF, and VDAC1 were validated and found to be down-regulated in diabetic nephropathy cases.
  • Gene set enrichment analysis revealed crucial pathways such as oxidative phosphorylation and glutathione metabolism.
  • A nomogram model was constructed to predict diabetic nephropathy outcomes based on these identified genes.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c24236b210217d647a28aahttps://doi.org/10.1038/s41598-025-11097-5
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