What question did this study set out to answer?

To establish a reliable process for large-scale production of NK and CAR-NK cells for immunotherapy.

November 25, 2025The Journal of ImmunologyOpen Access

Scalable Process Development of NK and CAR-NK Expansion in a Closed Bioreactor Using 721.221-mIL21 Expansion System 2440

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To establish a reliable process for large-scale production of NK and CAR-NK cells for immunotherapy.
Developed NK and CAR-NK cell expansion in G-Rex 100M bioreactors.
Utilized gas-permeable membrane technology to enhance oxygen delivery.
Evaluated the immunophenotypes and cytotoxicity against hepatocellular carcinoma cells.
Produced functional NK and CAR-NK cells in large volumes.
Cryopreservation minimally affected NK cell cytotoxicity when using G-Rex 100M bioreactors.
Established a robust platform for scalable NK cell production.

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Process development improves cytotoxicity of NK cells in bioreactors, indicating potential for scalable immunotherapy.

Dongfang Liu (2025) studied this question.

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