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September 10, 2025BMC BiotechnologyOpen Access

A novel feeder cell based on 4-1BBL and membrane-bound IL-21/IL-15 induce highly expansion and anti-tumor effect of natural killer cells

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Authors

SGSha GongSecond Affiliated Hospital of Xi'an Jiaotong UniversityNMNan MeiJWJun WangNanjing Tech University

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Implication

Novel K562 feeder cells enhancing NK cell expansion and anti-tumor efficacy, indicating promising therapy potential.

Key Points

  • NK cells demonstrated a 17902-fold expansion using K562-4-1BBL-mbIL-21/-15 feeder cells over two weeks.
  • The expanded NK cells showed enhanced cytotoxicity against various cancer cell lines, including AML and solid tumors.
  • In vivo tests displayed improved median survival for AML-bearing mice treated with expanded NK cells.
  • The platform represents a cost-effective method for rapid NK cell expansion, addressing previous clinical application limitations.

Cite This Study

Gong et al. (2025) studied this question.

synapsesocial.com/papers/68c24317b210217d647a61bbhttps://doi.org/10.1186/s12896-025-01024-x
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