PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
October 27, 2025European Journal of Preventive CardiologyOpen Access

Impact of weight/BMI on clinical and bleeding events in 26 805 atrial fibrillation patients on edoxaban from the Global ETNA-AF Registry

View Full Paper
Ask AI
Bookmark
Share

Authors

GBGiuseppe BorianiPKPaulus KirchhofJSJosé Souza

Discussion

Loading...

Member takes

Overview

Analysis shows U-shaped relationships between body weight/BMI and stroke risk in atrial fibrillation patients, indicating targeted monitoring may be necessary.

Key Points

  • U-shaped relationships were observed between body mass index and all-cause death within two years.
  • Annualized rates of stroke and bleeding events increased significantly in patients weighing ≤60 kg.
  • Patients weighing between 60 and 80 kg had the lowest death rates in the study.
  • Clinicians should intensify monitoring for AF patients with low body weight or BMI thresholds.

Cite This Study

Boriani et al. (2025) studied this question.

synapsesocial.com/papers/68ff87d8c8c50a61f2bdca7dhttps://doi.org/10.1093/eurjpc/zwaf685
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of renal impairment and other high bleeding risk factors on clinical outcomes among Asian patients with atrial fibrillation on edoxaban: a post hoc analysis of the ETNA-AF program2026
  2. 2Ablation outcome and post-interventional management of anticoagulation in patients with obesity or severe obesity and atrial fibrillation2026
  3. 3Dabigatran use and cerebrovascular event risk across body mass index in atrial fibrillation: a real-world nested case–control study2026
  4. 4Impact of Age on Bleeding, Stroke, and Mortality in Edoxaban-Treated Patients with Atrial Fibrillation: Results from the ETAF-TR Registry2026
  5. 5Association of diabetes mellitus status and clinical outcomes of edoxaban in patients with atrial fibrillation: a sub-analysis from the ETNA-AF Asian registry2026