Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 3, 2026CureusOpen Access

Evaluation of Outcomes After Early Versus Late Initiation of Continuous Renal Replacement Therapy in Adult Patients With Sepsis-Associated Acute Kidney Injury

View Full Paper
Ask AI
Bookmark
Share

Authors

SNSoumya Sankar NathHAHina AshrafRGRachana Gupta

Discussion

Loading...

Member takes

Overview

Randomized trial compares early versus late continuous renal replacement therapy outcomes in sepsis-associated acute kidney injury, indicating early therapy may be beneficial.

Key Points

  • This study aims to compare the effects of early and late initiation of continuous renal replacement therapy on mortality and recovery in patients with sepsis-associated acute kidney injury.
  • Screened 60 adult patients (18-65 years) with sepsis-associated acute kidney injury needing continuous renal replacement therapy.
  • Divided patients into early CRRT (KDIGO stage I/II) and late CRRT (KDIGO stage III or delayed initiation).
  • Analyzed data from 32 patients regarding mortality, renal recovery, and length of ICU stay.
  • 28-day mortality in early CRRT group was 4/25% compared to 7/43.75% in late group (p-value 0.048).
  • Length of ICU stay and blood transfusion needs were comparable between groups.
  • Renal recovery and requirement for renal replacement therapy on day 28 were also similar.

Cite This Study

Nath et al. (2026) studied this question.

synapsesocial.com/papers/6a4750f45c29257aa257873bhttps://doi.org/10.7759/cureus.111819
View Full Paper
Ask AI
Bookmark
Share