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October 23, 2025Immunological MedicineOpen Access

Long COVID: mechanisms of disease, multisystem sequelae, and prospects for treatment

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Authors

SOSeiya ObaTHTadashi HosoyaHIHideyuki Iwai

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Overview

Review highlights treatment prospects for long COVID by addressing fatigue and cardiovascular complications through immune dysregulation and antiviral agents.

Key Points

  • Cardiovascular complications were prevalent in long COVID, affecting quality of life and function.
  • Fatigue and cognitive dysfunction are common symptoms, impacting many individuals post-infection.
  • Review of known pathophysiological mechanisms points to immune dysregulation and mitochondrial impairment as critical factors.
  • Emerging antiviral agents and vaccination strategies may significantly reduce long COVID incidence.

Cite This Study

Oba et al. (2025) studied this question.

synapsesocial.com/papers/68f9840c1881b68f3b7ae718https://doi.org/10.1080/25785826.2025.2570902
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-COVID: Current Understanding and Future Directions2025
  2. 2Long COVID Symptom Management Through Self-Care and Nonprescription Treatment Options: A Narrative Review2025 · 1 citations
  3. 3Multiorgan Involvement and Particularly Liver Injury in Long COVID: A Narrative Review2025
  4. 4Cardio-Pulmonary Features of Long COVID: From Molecular and Histopathological Characteristics to Clinical Implications2025
  5. 5The Lingering Shadow of a Pandemic: A Comprehensive Literature Review on Long COVID2025