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October 15, 2025Journal of Applied Pharmaceutical ScienceOpen Access

Discovery of pyrazole–pyrazoline derivatives as VEGFR-2 kinase inhibitors: In silico approach

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Authors

DWDeepali WanodeKBKumud BhendarkarPKPramod B. Khedekar

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Overview

In silico research reveals C-64 as a potent VEGFR-2 inhibitor, suggesting improvements in cancer therapy.

Key Points

  • C-64 displayed strong binding affinity to VEGFR-2, indicating its potential as a cancer treatment.
  • Molecular docking with AutoDock Vina confirmed significant interactions of C-64 with VEGFR-2.
  • Pharmacokinetic predictions using SwissADME and pkCSM highlighted C-64's favorable drug-like properties.
  • C-64's low toxicity and high gastrointestinal absorption position it well for further research.

Cite This Study

Wanode et al. (2025) studied this question.

synapsesocial.com/papers/68efa18f9d05deea71d13f49https://doi.org/10.7324/japs.2026.256031
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Also Consider

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  1. 1VEGFR-2 as a druggable target: recent advances (2025) in the development of five-membered heterocyclic anticancer agents2026
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  3. 3Computational Exploration and Optimization of 6-Aryl-5-Cyano Thiouracil Scaffolds as Type-II VEGFR-2 Tyrosine Kinase Inhibitors: Insights from Docking, Molecular Dynamics, DFT, and ADMET Studies2026
  4. 4Design, synthesis, and cytotoxic evaluation of quinazoline-based derivatives as VEGER-2 inhibitors: comparative study against EGFR kinase activity, induction of apoptosis, and molecular docking study2025
  5. 5Sulfonamide Derivatives as Potent VEGFR-2 Inhibitors: Advances and Therapeutic Perspectives: A Comprehensive Review2025