January 1, 2025RSC AdvancesOpen Access

Design, synthesis, and cytotoxic evaluation of quinazoline-based derivatives as VEGER-2 inhibitors: comparative study against EGFR kinase activity, induction of apoptosis, and molecular docking study

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Novel quinazoline compounds inhibit VEGFR-2 and induce apoptosis, suggesting potential for cancer therapy.

The study reveals that new quinazoline-based derivatives effectively inhibit VEGFR-2 activity, alongside inducing apoptosis in cancer cells.
Key evidence shows significant cytotoxic effects against cancer cell lines, enhancing the therapeutic potential of these compounds.
Assessment used molecular docking techniques to explore binding affinities of quinazoline derivatives to VEGFR-2 and EGFR.
Findings suggest these compounds may serve as promising candidates in cancer treatment, warranting further investigation for clinical applications.

Mabrouk et al. (2025) studied this question.

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