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October 13, 2025Paediatrics & Child Health

Oral morphine pharmacokinetics in healthy children and the effect of genetic polymorphisms: An exploratory study

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Authors

LFLauren FaughtAEAbdelbaset ElzagallaaiNTNicholas C. Tonial

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Overview

Exploratory study investigates pharmacokinetics of oral morphine in children, highlighting genetic polymorphisms' role in efficacy and safety.

Key Points

  • In children, the pharmacokinetics of oral morphine reveal substantial variability among individuals.
  • A total of 13 children aged 5–17 were dosed with 0.5 mg/kg oral morphine, with median Cmax values of 14.07, 53.64, and 309.63 ng/mL for morphine and its metabolites.
  • Genotyping identified a SNP rs563649 associated with reduced receptor efficiency, impacting pain management in one patient.
  • Understanding genetic polymorphisms in drug response may improve treatment effectiveness and safety for pediatric patients.

Cite This Study

Faught et al. (2025) studied this question.

synapsesocial.com/papers/68ed3352c8c3d6f5ff5ddaedhttps://doi.org/10.1093/pch/pxaf084
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Also Consider

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  1. 1Pharmacogenomic-Based Oral Morphine Dose Adjustment: Is It Hard to Swallow?2025
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