Endothelin-1 as a biomarker of diabetic retinopathy and a factor in its progression

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This analysis assesses endothelin-1 levels in diabetic retinopathy patients, suggesting significant diagnostic and prognostic roles.

Endothelin-1 is significantly elevated in diabetic retinopathy patients, indicating its potential as a reliable biomarker.
In non-proliferative diabetic retinopathy, endothelin-1 levels exceeded those in controls by 2.2 times, while preproliferative and proliferative stages showed increases of 3.8–4.1 times.
The study involved 136 patients with type 2 diabetes, utilizing enzyme-linked immunosorbent assay to measure endothelin-1 levels over two years.
These findings support the use of endothelin-1 as a predictive biomarker for the progression of diabetic retinopathy; further study may enhance diagnostic approaches.

Mogilevskyy et al. (2025) studied this question.

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