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October 12, 2025Diabetes Obesity and MetabolismOpen Access

Partial non‐adherence to antidiabetic therapy undermines diabetes management and correlates with treatment complexity: A cross‐sectional study using blood plasma analysis

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Authors

VŠVojtěch ŠkopILIvana LaňkováSASimona Antalová

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Overview

Cross-sectional analysis reveals non-adherence rates in type 2 diabetes patients, highlighting treatment complexity's role in glycemic control.

Key Points

  • Partial non-adherence to antidiabetic therapy strongly correlates with treatment complexity and poor glycemic control.
  • Around 63% of non-adherent type 2 diabetes patients failed to achieve target glucose and HbA1c levels.
  • Plasma drug measurements using LC–MS show metformin adherence at 98.1%, while non-adherence is prevalent for other antidiabetics.
  • The study indicates the necessity for personalized strategies to enhance adherence and improve diabetes management.

Cite This Study

Škop et al. (2025) studied this question.

synapsesocial.com/papers/68ebabe3155248a327effb1bhttps://doi.org/10.1111/dom.70174
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevalence and Predictors of Non-Adherence to Treatment in Patients with Type 2 Diabetes Mellitus2025 · 1 citations
  2. 2Improving medication adherence in type 2 diabetes: strategies for better clinical and economic outcomes2025 · 11 citations
  3. 3Adherence patterns to cardiovascular medications in people with type 2 diabetes mellitus: a retrospective cohort study using group-based trajectory analysis in primary care2025 · 3 citations
  4. 4Level of medication non-adherence among ambulatory patients with dyslipidemia and comorbid illness in Northwest Ethiopia: a multicenter cross-sectional study2025
  5. 5Poor adherence to oral antidiabetic drugs among people living with type 2 diabetes mellitus in two healthcare facilities in the West Region (Cameroon): a cross-sectional study2025